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BMCBI
2004
75views more  BMCBI 2004»
13 years 7 months ago
Structural characterization of genomes by large scale sequence-structure threading
Background: Using sequence-structure threading we have conducted structural characterization of complete proteomes of 37 archaeal, bacterial and eukaryotic organisms (including wo...
Artem Cherkasov, Steven J. M. Jones
SC
2004
ACM
14 years 24 days ago
A Performance and Scalability Analysis of the BlueGene/L Architecture
This paper is structured as follows. Section 2 gives an architectural description of BlueGene/L. Section 3 analyzes the issue of “computational noise” – the effect that the o...
Kei Davis, Adolfy Hoisie, Greg Johnson, Darren J. ...
BMCBI
2007
145views more  BMCBI 2007»
13 years 7 months ago
Genome bioinformatic analysis of nonsynonymous SNPs
Background: Genome-wide association studies of common diseases for common, low penetrance causal variants are underway. A proportion of these will alter protein sequences, the mos...
David F. Burke, Catherine L. Worth, Eva-Maria Prie...
BMCBI
2006
134views more  BMCBI 2006»
13 years 7 months ago
Application of machine learning in SNP discovery
Background: Single nucleotide polymorphisms (SNP) constitute more than 90% of the genetic variation, and hence can account for most trait differences among individuals in a given ...
Lakshmi K. Matukumalli, John J. Grefenstette, Davi...
BMCBI
2010
125views more  BMCBI 2010»
13 years 2 months ago
ProbFAST: Probabilistic Functional Analysis System Tool
Background: The post-genomic era has brought new challenges regarding the understanding of the organization and function of the human genome. Many of these challenges are centered...
Israel T. da Silva, Ricardo Z. N. Vêncio, Th...