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RECOMB
2009
Springer
14 years 2 months ago
Protein Fragment Swapping: A Method for Asymmetric, Selective Site-Directed Recombination
This paper presents a new approach to site-directed recombination, swapping combinations of selected discontiguous fragments from a source protein in place of corresponding fragmen...
Wei Zheng, Karl E. Griswold, Chris Bailey-Kellogg
GECCO
2004
Springer
164views Optimization» more  GECCO 2004»
14 years 25 days ago
Fuzzy Dominance Based Multi-objective GA-Simplex Hybrid Algorithms Applied to Gene Network Models
Hybrid algorithms that combine genetic algorithms with the Nelder-Mead simplex algorithm have been effective in solving certain optimization problems. In this article, we apply a s...
Praveen Koduru, Sanjoy Das, Stephen Welch, Judith ...
ICML
2001
IEEE
14 years 8 months ago
Feature selection for high-dimensional genomic microarray data
We report on the successful application of feature selection methods to a classification problem in molecular biology involving only 72 data points in a 7130 dimensional space. Ou...
Eric P. Xing, Michael I. Jordan, Richard M. Karp
ICAPR
2005
Springer
14 years 29 days ago
Hierarchical Clustering of Dynamical Systems Based on Eigenvalue Constraints
Abstract. This paper addresses the clustering problem of hidden dynamical systems behind observed multivariate sequences by assuming an interval-based temporal structure in the seq...
Hiroaki Kawashima, Takashi Matsuyama
BMCBI
2006
122views more  BMCBI 2006»
13 years 7 months ago
A multivariate prediction model for microarray cross-hybridization
Background: Expression microarray analysis is one of the most popular molecular diagnostic techniques in the post-genomic era. However, this technique faces the fundamental proble...
Yian A. Chen, Cheng-Chung Chou, Xinghua Lu, Elizab...