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NAR
2010
135views more  NAR 2010»
13 years 2 months ago
ALTER: program-oriented conversion of DNA and protein alignments
ALTER is an open web-based tool to transform between different multiple sequence alignment formats. The originality of ALTER lies in the fact that it focuses on the specifications...
Daniel Glez-Peña, Daniel Gómez-Blanc...
BMCBI
2006
92views more  BMCBI 2006»
13 years 7 months ago
A jumping profile Hidden Markov Model and applications to recombination sites in HIV and HCV genomes
Background: Jumping alignments have recently been proposed as a strategy to search a given multiple sequence alignment A against a database. Instead of comparing a database sequen...
Anne-Kathrin Schultz, Ming Zhang, Thomas Leitner, ...
BMCBI
2007
117views more  BMCBI 2007»
13 years 7 months ago
Supervised multivariate analysis of sequence groups to identify specificity determining residues
Background: Proteins that evolve from a common ancestor can change functionality over time, and it is important to be able identify residues that cause this change. In this paper ...
Iain M. Wallace, Desmond G. Higgins
BMCBI
2004
177views more  BMCBI 2004»
13 years 7 months ago
Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model
Background: Certain protein families are highly conserved across distantly related organisms and belong to large and functionally diverse superfamilies. The patterns of conservati...
Andrew F. Neuwald, Jun S. Liu
AAAI
2004
13 years 9 months ago
PROBCONS: Probabilistic Consistency-Based Multiple Alignment of Amino Acid Sequences
Obtaining an accurate multiple alignment of protein sequences is a difficult computational problem for which many heuristic techniques sacrifice optimality to achieve reasonable r...
Chuong B. Do, Michael Brudno, Serafim Batzoglou