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» Identifying Protein Flexibility by NMA
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ICCAD
2009
IEEE
147views Hardware» more  ICCAD 2009»
13 years 4 months ago
SAT-based protein design
Computational protein design can be formulated as an optimization problem, where the objective is to identify the sequence of amino acids that minimizes the energy of a given prot...
Noah Ollikainen, Ellen Sentovich, Carlos Coelho, A...
BMCBI
2006
85views more  BMCBI 2006»
13 years 7 months ago
Identification of physicochemical selective pressure on protein encoding nucleotide sequences
Background: Statistical methods for identifying positively selected sites in protein coding regions are one of the most commonly used tools in evolutionary bioinformatics. However...
Wendy S. W. Wong, Raazesh Sainudiin, Rasmus Nielse...
BMCBI
2008
104views more  BMCBI 2008»
13 years 7 months ago
InteroPORC: an automated tool to predict highly conserved protein interaction networks
teps. First, we abstracted protein interactions onto orthologous cluster links. For a given source interaction, if both proteins belonged to a cluster, we constructed a link betwee...
Magali Michaut, Samuel Kerrien, Luisa Montecchi-Pa...
BMCBI
2007
137views more  BMCBI 2007»
13 years 7 months ago
Bayesian refinement of protein functional site matching
Background: Matching functional sites is a key problem for the understanding of protein function and evolution. The commonly used graph theoretic approach, and other related appro...
Kanti V. Mardia, Vysaul B. Nyirongo, Peter J. Gree...
BMCBI
2008
176views more  BMCBI 2008»
13 years 7 months ago
H2r: Identification of evolutionary important residues by means of an entropy based analysis of multiple sequence alignments
Background: A multiple sequence alignment (MSA) generated for a protein can be used to characterise residues by means of a statistical analysis of single columns. In addition to t...
Rainer Merkl, Matthias Zwick