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» Incremental Signaling Pathway Modeling by Data Integration
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BMCBI
2007
166views more  BMCBI 2007»
13 years 6 months ago
PathFinder: mining signal transduction pathway segments from protein-protein interaction networks
Background: A Signal transduction pathway is the chain of processes by which a cell converts an extracellular signal into a response. In most unicellular organisms, the number of ...
Gürkan Bebek, Jiong Yang
BMCBI
2010
126views more  BMCBI 2010»
13 years 4 months ago
PETALS: Proteomic Evaluation and Topological Analysis of a mutated Locus' Signaling
Background: Colon cancer is driven by mutations in a number of genes, the most notorious of which is Apc. Though much of Apc's signaling has been mechanistically identified o...
Gürkan Bebek, Vishal Patel, Mark R. Chance
BMCBI
2008
133views more  BMCBI 2008»
13 years 6 months ago
SPIKE - a database, visualization and analysis tool of cellular signaling pathways
Background: Biological signaling pathways that govern cellular physiology form an intricate web of tightly regulated interlocking processes. Data on these regulatory networks are ...
Ran Elkon, Rita Vesterman, Nira Amit, Igor Ulitsky...
BMCBI
2006
205views more  BMCBI 2006»
13 years 6 months ago
Application of Petri net based analysis techniques to signal transduction pathways
Background: Signal transduction pathways are usually modelled using classical quantitative methods, which are based on ordinary differential equations (ODEs). However, some diffic...
Andrea Sackmann, Monika Heiner, Ina Koch
CMSB
2009
Springer
13 years 10 months ago
On the Use of Stochastic Petri Nets in the Analysis of Signal Transduction Pathways for Angiogenesis Process
In this paper we consider the modeling of a selected portion of signal transduction events involved in the angiogenesis process. The detailed model of this process contains a large...
Lucia Napione, Daniele Manini, Francesca Cordero, ...