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NAR
2011
305views Computer Vision» more  NAR 2011»
12 years 10 months ago
CDD: a Conserved Domain Database for the functional annotation of proteins
NCBI’s Conserved Domain Database (CDD) is a resource for the annotation of protein sequences with the location of conserved domain footprints, and functional sites inferred from...
Aron Marchler-Bauer, Shennan Lu, John B. Anderson,...
BMCBI
2008
130views more  BMCBI 2008»
13 years 7 months ago
A novel series of compositionally biased substitution matrices for comparing Plasmodium proteins
Background: The most common substitution matrices currently used (BLOSUM and PAM) are based on protein sequences with average amino acid distributions, thus they do not represent ...
Kevin Brick, Elisabetta Pizzi
BMCBI
2006
117views more  BMCBI 2006»
13 years 7 months ago
Incorporating background frequency improves entropy-based residue conservation measures
Background: Several entropy-based methods have been developed for scoring sequence conservation in protein multiple sequence alignments. High scoring amino acid positions may corr...
Kai Wang, Ram Samudrala
CPM
2000
Springer
141views Combinatorics» more  CPM 2000»
13 years 10 months ago
A Lower Bound for the Breakpoint Phylogeny Problem
Breakpoint phylogenies methods have been shown to be an effective way to extract phylogenetic information from gene order data. Currently, the only practical breakpoint phylogeny a...
David Bryant
BMCBI
2006
114views more  BMCBI 2006»
13 years 7 months ago
A direct comparison of protein interaction confidence assignment schemes
Background: Recent technological advances have enabled high-throughput measurements of protein-protein interactions in the cell, producing large protein interaction networks for v...
Silpa Suthram, Tomer Shlomi, Eytan Ruppin, Roded S...