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JCNS
2002
62views more  JCNS 2002»
13 years 8 months ago
Computing Transient Gating Charge Movement of Voltage-Dependent Ion Channels
The opening of voltage-gated sodium, potassium, and calcium ion channels has a steep relationship with voltage. In response to changes in the transmembrane voltage, structural move...
Anthony Varghese, Linda M. Boland
TCBB
2011
13 years 3 months ago
Semi-Markov Models for Brownian Dynamics Permeation in Biological Ion Channels
—Constructing accurate computational models that explain how ions permeate through a biological ion channel is an important problem in biophysics and drug design. Brownian dynami...
Vikram Krishnamurthy, Kai Yiu Luk
WSC
1998
13 years 10 months ago
Modeling Cardiac Ion Channel Conductivity: Model Fitting via Simulation
We describe a Markov state model for a cloned potassium channel of the human heart ( 1KvLQTI ). The parameters of the model are determined by a least-squares fit of predicted vs. ...
John L. Maryak, Richard H. Smith, Raimond L. Winsl...
TSP
2008
106views more  TSP 2008»
13 years 8 months ago
An EM Algorithm for Ion-Channel Current Estimation
Parameter estimation of a continuous-time Markov chain observed through a discrete-time memoryless channel is studied. An expectation-maximization (EM) algorithm for maximum likeli...
William J. J. Roberts, Yariv Ephraim
ICANN
2009
Springer
14 years 3 months ago
Acquiring and Classifying Signals from Nanopores and Ion-Channels
The use of engineered nanopores as sensing elements for chemical and biological agents is a rapidly developing area. The distinct signatures of nanopore-nanoparticle lend themselve...
Bharatan Konnanath, Prasanna Sattigeri, Trupthi Ma...