The opening of voltage-gated sodium, potassium, and calcium ion channels has a steep relationship with voltage. In response to changes in the transmembrane voltage, structural move...
—Constructing accurate computational models that explain how ions permeate through a biological ion channel is an important problem in biophysics and drug design. Brownian dynami...
We describe a Markov state model for a cloned potassium channel of the human heart ( 1KvLQTI ). The parameters of the model are determined by a least-squares fit of predicted vs. ...
John L. Maryak, Richard H. Smith, Raimond L. Winsl...
Parameter estimation of a continuous-time Markov chain observed through a discrete-time memoryless channel is studied. An expectation-maximization (EM) algorithm for maximum likeli...
The use of engineered nanopores as sensing elements for chemical and biological agents is a rapidly developing area. The distinct signatures of nanopore-nanoparticle lend themselve...