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NAR
2008
152views more  NAR 2008»
13 years 8 months ago
PROMALS3D web server for accurate multiple protein sequence and structure alignments
Multiple sequence alignments are essential in computational sequence and structural analysis, with applications in homology detection, structure modeling, function prediction and ...
Jimin Pei, Ming Tang, Nick V. Grishin
BMCBI
2002
95views more  BMCBI 2002»
13 years 8 months ago
The functional importance of disease-associated mutation
Background: For many years, scientists believed that point mutations in genes are the genetic switches for somatic and inherited diseases such as cystic fibrosis, phenylketonuria ...
Sean D. Mooney, Teri E. Klein
NAR
2007
65views more  NAR 2007»
13 years 8 months ago
STRING 7 - recent developments in the integration and prediction of protein interactions
Information on protein–protein interactions is still mostly limited to a small number of model organisms, and originates from a wide variety of experimental and computational te...
Christian von Mering, Lars Juhl Jensen, Michael Ku...
WABI
2009
Springer
162views Bioinformatics» more  WABI 2009»
14 years 3 months ago
Aligning Biomolecular Networks Using Modular Graph Kernels
Comparative analysis of biomolecular networks constructed using measurements from different conditions, tissues, and organisms offer a powerful approach to understanding the stru...
Fadi Towfic, M. Heather West Greenlee, Vasant Hona...
NIPS
2008
13 years 10 months ago
A mixture model for the evolution of gene expression in non-homogeneous datasets
We address the challenge of assessing conservation of gene expression in complex, non-homogeneous datasets. Recent studies have demonstrated the success of probabilistic models in...
Gerald Quon, Yee Whye Teh, Esther Chan, Timothy R....