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NAR
1998
86views more  NAR 1998»
13 years 6 months ago
Pfam: multiple sequence alignments and HMM-profiles of protein domains
Pfam contains multiple alignments and hidden Markov model based profiles (HMM-profiles) of complete protein domains. The definition of domain boundaries, family members and alignm...
Erik L. L. Sonnhammer, Sean R. Eddy, Ewan Birney, ...
ICML
2004
IEEE
14 years 8 months ago
A graphical model for protein secondary structure prediction
In this paper, we present a graphical model for protein secondary structure prediction. This model extends segmental semi-Markov models (SSMM) to exploit multiple sequence alignme...
Wei Chu, Zoubin Ghahramani, David L. Wild
RECOMB
2003
Springer
14 years 7 months ago
An integrated probabilistic model for functional prediction of proteins
We develop an integrated probabilistic model to combine protein physical interactions, genetic interactions, highly correlated gene expression network, protein complex data, and d...
Minghua Deng, Ting Chen, Fengzhu Sun
BMCBI
2004
123views more  BMCBI 2004»
13 years 7 months ago
Interaction profile-based protein classification of death domain
Background: The increasing number of protein sequences and 3D structure obtained from genomic initiatives is leading many of us to focus on proteomics, and to dedicate our experim...
Drew Lett, Michael Hsing, Frederic Pio
AIED
2009
Springer
14 years 1 months ago
Discovering Tutorial Dialogue Strategies with Hidden Markov Models
Identifying effective tutorial strategies is a key problem for tutorial dialogue systems research. Ongoing work in human-human tutorial dialogue continues to reveal the complex phe...
Kristy Elizabeth Boyer, Eunyoung Ha, Michael D. Wa...