Interaction profile-based protein classification of death domain

Background: The increasing number of protein sequences and 3D structure obtained from genomic initiatives is leading many of us to focus on proteomics, and to dedicate our experimental and computational efforts on the creation and analysis of information derived from 3D structure. In particular, the high-throughput generation of protein-protein interaction data from a few organisms makes such an approach very important towards understanding the molecular recognition that make-up the entire protein-protein interaction network. Since the generation of sequences, and experimental protein-protein interactions increases faster than the 3D structure determination of protein complexes, there is tremendous interest in developing in silico methods that generate such structure for prediction and classification purposes. In this study we focused on classifying protein family members based on their protein-protein interaction distinctiveness. Structure-based classification of protein-protein inte...

• Type: Journal
• Year: 2004
• Where: BMCBI
• Authors: Drew Lett, Michael Hsing, Frederic Pio
• Keywords: BMCBI 2004, Entire Protein-protein Interaction, Protein-protein Interaction, Protein-protein Interaction Data