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» Models and Methods in Comparative Genomics
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BMCBI
2006
169views more  BMCBI 2006»
13 years 11 months ago
Comparative analysis of haplotype association mapping algorithms
Background: Finding the genetic causes of quantitative traits is a complex and difficult task. Classical methods for mapping quantitative trail loci (QTL) in miceuse an F2 cross b...
Phillip McClurg, Mathew T. Pletcher, Tim Wiltshire...
BMCBI
2004
135views more  BMCBI 2004»
13 years 10 months ago
Information assessment on predicting protein-protein interactions
Background: Identifying protein-protein interactions is fundamental for understanding the molecular machinery of the cell. Proteome-wide studies of protein-protein interactions ar...
Nan Lin, Baolin Wu, Ronald Jansen, Mark Gerstein, ...
BMCBI
2005
302views more  BMCBI 2005»
13 years 11 months ago
CGHPRO - A comprehensive data analysis tool for array CGH
Background: Array CGH (Comparative Genomic Hybridisation) is a molecular cytogenetic technique for the genome wide detection of chromosomal imbalances. It is based on the cohybrid...
Wei Chen, Fikret Erdogan, H.-Hilger Ropers, Steffe...
BMCBI
2008
89views more  BMCBI 2008»
13 years 11 months ago
Increasing the efficiency of bacterial transcription simulations: When to exclude the genome without loss of accuracy
Background: Simulating the major molecular events inside an Escherichia coli cell can lead to a very large number of reactions that compose its overall behaviour. Not only should ...
Marco A. J. Iafolla, Guang Qiang Dong, David R. Mc...
BMCBI
2007
80views more  BMCBI 2007»
13 years 11 months ago
AT excursion: a new approach to predict replication origins in viral genomes by locating AT-rich regions
Background: Replication origins are considered important sites for understanding the molecular mechanisms involved in DNA replication. Many computational methods have been develop...
David S. H. Chew, Ming-Ying Leung, Kwok Pui Choi