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» Models and Methods in Comparative Genomics
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BMCBI
2008
107views more  BMCBI 2008»
13 years 11 months ago
A mixture model approach to sample size estimation in two-sample comparative microarray experiments
Background: Choosing the appropriate sample size is an important step in the design of a microarray experiment, and recently methods have been proposed that estimate sample sizes ...
Tommy S. Jørstad, Herman Midelfart, Atle M....
EVOW
2010
Springer
14 years 5 months ago
Towards Automatic Detecting of Overlapping Genes - Clustered BLAST Analysis of Viral Genomes
Overlapping genes (encoded on the same DNA strand but in different frames) are thought to be rare and, therefore, were largely neglected in the past. In a test set of 800 viruses ...
Klaus Neuhaus, Daniela Oelke, David Fürst, Si...
RECOMB
2006
Springer
14 years 11 months ago
A Parsimony Approach to Genome-Wide Ortholog Assignment
The assignment of orthologous genes between a pair of genomes is a fundamental and challenging problem in comparative genomics, since many computational methods for solving various...
Zheng Fu, Xin Chen, Vladimir Vacic, Peng Nan, Yang...
BIOSURVEILLANCE
2007
Springer
14 years 5 months ago
Detecting Conserved RNA Secondary Structures in Viral Genomes: The RADAR Approach
Abstract. Conserved regions, or motifs, present among RNA secondary structures serve as a useful indicator for predicting the functionality of the RNA molecules. Automated detectio...
Mugdha Khaladkar, Jason T. L. Wang
APBC
2004
166views Bioinformatics» more  APBC 2004»
14 years 12 days ago
THEMATICS is Effective for Active Site Prediction in Comparative Model Structures
THEMATICS (Theoretical Microscopic Titration Curves) is a simple, reliable computational predictor of the active sites of enzymes from structure. Our method, based on well-establi...
Ihsan A. Shehadi, Alper Uzun, Leonel F. Murga, Val...