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BMCBI
2007
105views more  BMCBI 2007»
13 years 7 months ago
VaxiJen: a server for prediction of protective antigens, tumour antigens and subunit vaccines
Background: Vaccine development in the post-genomic era often begins with the in silico screening of genome information, with the most probable protective antigens being predicted...
Irini A. Doytchinova, Darren R. Flower
BMCBI
2006
101views more  BMCBI 2006»
13 years 7 months ago
Predicting residue contacts using pragmatic correlated mutations method: reducing the false positives
Background: Predicting residues' contacts using primary amino acid sequence alone is an important task that can guide 3D structure modeling and can verify the quality of the ...
Petras J. Kundrotas, Emil Alexov
BMCBI
2007
145views more  BMCBI 2007»
13 years 7 months ago
Genome bioinformatic analysis of nonsynonymous SNPs
Background: Genome-wide association studies of common diseases for common, low penetrance causal variants are underway. A proportion of these will alter protein sequences, the mos...
David F. Burke, Catherine L. Worth, Eva-Maria Prie...
IPPS
2006
IEEE
14 years 1 months ago
A method to improve structural modeling based on conserved domain clusters
—Homology modeling requires an accurate alignment between a query sequence and its homologs with known three-dimensional (3D) information. Current structural modeling techniques ...
Fa Zhang, Lin Xu, Bo Yuan
BMCBI
2008
97views more  BMCBI 2008»
13 years 7 months ago
SiteSeek: Post-translational modification analysis using adaptive locality-effective kernel methods and new profiles
Background: Post-translational modifications have a substantial influence on the structure and functions of protein. Post-translational phosphorylation is one of the most common m...
Paul D. Yoo, Yung Shwen Ho, Bing Bing Zhou, Albert...