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BMCBI
2010
90views more  BMCBI 2010»
13 years 9 months ago
Local alignment of generalized k-base encoded DNA sequence
Background: DNA sequence comparison is a well-studied problem, in which two DNA sequences are compared using a weighted edit distance. Recent DNA sequencing technologies however o...
Nils Homer, Stanley F. Nelson, Barry Merriman
BMCBI
2008
173views more  BMCBI 2008»
13 years 9 months ago
Extraction of semantic biomedical relations from text using conditional random fields
Background: The increasing amount of published literature in biomedicine represents an immense source of knowledge, which can only efficiently be accessed by a new generation of a...
Markus Bundschus, Mathäus Dejori, Martin Stet...
BMCBI
2007
113views more  BMCBI 2007»
13 years 9 months ago
In silico panning for a non-competitive peptide inhibitor
Background: Peptide ligands have tremendous therapeutic potential as efficacious drugs. Currently, more than 40 peptides are available in the market for a drug. However, since cos...
Yukiko Yagi, Kotaro Terada, Takahisa Noma, Kazunor...
BMCBI
2008
123views more  BMCBI 2008»
13 years 9 months ago
Functional module detection by functional flow pattern mining in protein interaction networks
eraction networks. In this abstract, we extend this approach by mining functional flow patterns for the purpose of detecting small-sized modules for specific functions. Methods Our...
Young-Rae Cho, Lei Shi, Aidong Zhang
COR
2010
123views more  COR 2010»
13 years 9 months ago
Decomposition, reformulation, and diving in university course timetabling
In many real-life optimisation problems, there are multiple interacting components in a solution. For example, different components might specify assignments to different kinds of...
Edmund K. Burke, Jakub Marecek, Andrew J. Parkes, ...