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» On Compressibility of Protein Sequences
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JCB
2002
116views more  JCB 2002»
13 years 9 months ago
A Novel Approach to Remote Homology Detection: Jumping Alignments
We describe a new algorithm for protein classi cation and the detection of remote homologs. The rationale is to exploit both vertical and horizontal information of a multiple alig...
Rainer Spang, Marc Rehmsmeier, Jens Stoye
BIRD
2008
Springer
109views Bioinformatics» more  BIRD 2008»
14 years 4 days ago
A Robust Class of Stable Proteins in the 2D HPC Model
The inverse protein folding problem is that of designing an amino acid sequence which has a prescribed native protein fold. This problem arises in drug design where a particular st...
Alireza Hadj Khodabakhshi, Ján Manuch, Aras...
BMCBI
2010
131views more  BMCBI 2010»
13 years 10 months ago
FACT: Functional annotation transfer between proteins with similar feature architectures
Background: The increasing number of sequenced genomes provides the basis for exploring the genetic and functional diversity within the tree of life. Only a tiny fraction of the e...
Tina Koestler, Arndt von Haeseler, Ingo Ebersberge...
BMCBI
2007
109views more  BMCBI 2007»
13 years 10 months ago
Towards a comprehensive structural coverage of completed genomes: a structural genomics viewpoint
Background: Structural genomics initiatives were established with the aim of solving protein structures on a large-scale. For many initiatives, such as the Protein Structure Initi...
Russell L. Marsden, Tony A. Lewis, Christine A. Or...
BMCBI
2006
111views more  BMCBI 2006»
13 years 10 months ago
Development of an unbiased statistical method for the analysis of unigenic evolution
Background: Unigenic evolution is a powerful genetic strategy involving random mutagenesis of a single gene product to delineate functionally important domains of a protein. This ...
Colleen D. Behrsin, Chris J. Brandl, David W. Litc...