Towards a comprehensive structural coverage of completed genomes: a structural genomics viewpoint

Background: Structural genomics initiatives were established with the aim of solving protein structures on a large-scale. For many initiatives, such as the Protein Structure Initiative (PSI), the primary aim of target selection is focussed towards structurally characterising protein families which, so far, lack a structural representative. It is therefore of considerable interest to gain insights into the number and distribution of these families, and what efforts may be required to achieve a comprehensive structural coverage across all protein families. Results: In this analysis we have derived a comprehensive domain annotation of the genomes using CATH, Pfam-A and Newfam domain families. We consider what proportions of structurally uncharacterised families are accessible to high-throughput structural genomics pipelines, specifically those targeting families containing multiple prokaryotic orthologues. In measuring the domain coverage of the genomes, we show the benefits of selecting...

• Type: Journal
• Year: 2007
• Where: BMCBI
• Authors: Russell L. Marsden, Tony A. Lewis, Christine A. Orengo
• Keywords: BMCBI 2007, Protein, Protein Structures, Structural