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» On Timed Models of Gene Networks
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BMCBI
2007
143views more  BMCBI 2007»
13 years 8 months ago
Factor analysis for gene regulatory networks and transcription factor activity profiles
Background: Most existing algorithms for the inference of the structure of gene regulatory networks from gene expression data assume that the activity levels of transcription fact...
Iosifina Pournara, Lorenz Wernisch
BMCBI
2011
12 years 11 months ago
RegNetB: Predicting Relevant Regulator-Gene Relationships in Localized Prostate Tumor Samples
Background: A central question in cancer biology is what changes cause a healthy cell to form a tumor. Gene expression data could provide insight into this question, but it is dif...
Angel Alvarez, Peter J. Woolf
BMCBI
2008
120views more  BMCBI 2008»
13 years 8 months ago
A protein interaction based model for schizophrenia study
Background: Schizophrenia is a complex disease with multiple factors contributing to its pathogenesis. In addition to environmental factors, genetic factors may also increase susc...
Pei-Chun Hsu, Ueng-Cheng Yang, Kuan-Hui Shih, Chih...
EUROGP
2010
Springer
217views Optimization» more  EUROGP 2010»
14 years 2 months ago
Evolving Genes to Balance a Pole
We discuss how to use a Genetic Regulatory Network as an evolutionary representation to solve a typical GP reinforcement problem, the pole balancing. The network is a modified ver...
Miguel Nicolau, Marc Schoenauer, Wolfgang Banzhaf
RECOMB
2005
Springer
14 years 8 months ago
Causal Inference of Regulator-Target Pairs by Gene Mapping of Expression Phenotypes
Background: Correlations between polymorphic markers and observed phenotypes provide the basis for mapping traits in quantitative genetics. When the phenotype is gene expression, ...
David Kulp, Manjunatha Jagalur