Sciweavers

85 search results - page 6 / 17
» Optimization algorithms for functional deimmunization of the...
Sort
View
BMCBI
2008
228views more  BMCBI 2008»
13 years 7 months ago
Adaptive diffusion kernel learning from biological networks for protein function prediction
Background: Machine-learning tools have gained considerable attention during the last few years for analyzing biological networks for protein function prediction. Kernel methods a...
Liang Sun, Shuiwang Ji, Jieping Ye
BMCBI
2007
216views more  BMCBI 2007»
13 years 7 months ago
A replica exchange Monte Carlo algorithm for protein folding in the HP model
Background: The ab initio protein folding problem consists of predicting protein tertiary structure from a given amino acid sequence by minimizing an energy function; it is one of...
Chris Thachuk, Alena Shmygelska, Holger H. Hoos
GECCO
2006
Springer
133views Optimization» more  GECCO 2006»
13 years 11 months ago
String transformation-based Bayesian classification or proteins
We describe a Markov chain Bayesian classification tool, SCS, that can perform data-driven classification of proteins and protein segments. Training data for interesting classific...
Timothy Meekhof, Gary W. Daughdrill, Robert B. Hec...
ICCAD
2009
IEEE
147views Hardware» more  ICCAD 2009»
13 years 5 months ago
SAT-based protein design
Computational protein design can be formulated as an optimization problem, where the objective is to identify the sequence of amino acids that minimizes the energy of a given prot...
Noah Ollikainen, Ellen Sentovich, Carlos Coelho, A...
GECCO
2000
Springer
127views Optimization» more  GECCO 2000»
13 years 11 months ago
Evolving Molecules for Drug Design Using Genetic Algorithms via Molecular Trees
We present a new representation for a genetic algorithm to evolve molecular structures representing possible drugs that bind to a given protein target receptor. Our representation...
Gerard Kian-Meng Goh, James A. Foster