Background: The modeling of dynamic systems requires estimating kinetic parameters from experimentally measured time-courses. Conventional global optimization methods used for par...
Background: The simulation of metabolic networks in quantitative systems biology requires the assignment of enzymatic kinetic parameters. Experimentally determined values are ofte...
Razif R. Gabdoulline, Matthias Stein, Rebecca C. W...
Background: The importance of stochasticity in cellular processes having low number of molecules has resulted in the development of stochastic models such as chemical master equat...
Background: The progress in the "-omic" sciences has allowed a deeper knowledge on many biological systems with industrial interest. This knowledge is still rarely used ...
Ana P. Teixeira, Carlos Alves, Paula M. Alves, Man...
Recently, there has been growing interest in the modelling and simulation of biological systems. Such systems are often modelled in terms of coupled ordinary differential equation...