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» Performance Analysis of Sequence Alignment Applications
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BMCBI
2010
125views more  BMCBI 2010»
13 years 4 months ago
ProbFAST: Probabilistic Functional Analysis System Tool
Background: The post-genomic era has brought new challenges regarding the understanding of the organization and function of the human genome. Many of these challenges are centered...
Israel T. da Silva, Ricardo Z. N. Vêncio, Th...
BMCBI
2010
97views more  BMCBI 2010»
13 years 9 months ago
Kinome-wide interaction modelling using alignment-based and alignment-independent approaches for kinase description and linear a
Background: Protein kinases play crucial roles in cell growth, differentiation, and apoptosis. Abnormal function of protein kinases can lead to many serious diseases, such as canc...
Maris Lapinsh, Jarl E. S. Wikberg
BMCBI
2008
103views more  BMCBI 2008»
13 years 9 months ago
Detection of protein catalytic residues at high precision using local network properties
Background: Identifying the active site of an enzyme is a crucial step in functional studies. While protein sequences and structures can be experimentally characterized, determini...
Patrick Slama, Ioannis Filippis, Michael Lappe
SODA
1997
ACM
144views Algorithms» more  SODA 1997»
13 years 10 months ago
Methods for Achieving Fast Query Times in Point Location Data Structures
Given a collection S of n line segments in the plane, the planar point location problem is to construct a data structure that can e ciently determine for a given query point p the...
Michael T. Goodrich, Mark W. Orletsky, Kumar Ramai...
BMCBI
2008
136views more  BMCBI 2008»
13 years 9 months ago
An efficient method for the prediction of deleterious multiple-point mutations in the secondary structure of RNAs using suboptim
Background: RNAmute is an interactive Java application which, given an RNA sequence, calculates the secondary structure of all single point mutations and organizes them into categ...
Alexander Churkin, Danny Barash