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BMCBI
2010
127views more  BMCBI 2010»
13 years 9 months ago
SplicerAV: a tool for mining microarray expression data for changes in RNA processing
Background: Over the past two decades more than fifty thousand unique clinical and biological samples have been assayed using the Affymetrix HG-U133 and HG-U95 GeneChip microarray...
Timothy J. Robinson, Michaela A. Dinan, Mark Dewhi...
BMCBI
2007
122views more  BMCBI 2007»
13 years 9 months ago
Dissecting complex transcriptional responses using pathway-level scores based on prior information
Background: The genomewide pattern of changes in mRNA expression measured using DNA microarrays is typically a complex superposition of the response of multiple regulatory pathway...
Harmen J. Bussemaker, Lucas D. Ward, André ...
BMCBI
2006
117views more  BMCBI 2006»
13 years 9 months ago
Gene Designer: a synthetic biology tool for constructing artificial DNA segments
Background: Direct synthesis of genes is rapidly becoming the most efficient way to make functional genetic constructs and enables applications such as codon optimization, RNAi re...
Alan Villalobos, Jon E. Ness, Claes Gustafsson, Je...
BMCBI
2005
79views more  BMCBI 2005»
13 years 8 months ago
Mathematical design of prokaryotic clone-based microarrays
Background: Clone-based microarrays, on which each spot represents a random genomic fragment, are a good alternative to open reading frame-based microarrays, especially for microo...
Bart Pieterse, Elisabeth J. Quirijns, Frank H. J. ...
ECAL
2005
Springer
14 years 2 months ago
CelloS: A Multi-level Approach to Evolutionary Dynamics
We study the evolution of simple cells that are equipped with a genome, a rudimentary gene regulation network at transcription level and two classes of functional genes: motion eï¬...
Camille Stephan-Otto Attolini, Peter F. Stadler, C...