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» Predicting Gene Structures from Multiple RT-PCR Tests
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BMCBI
2010
113views more  BMCBI 2010»
13 years 7 months ago
Improving performance of mammalian microRNA target prediction
Background: MicroRNAs (miRNAs) are single-stranded non-coding RNAs known to regulate a wide range of cellular processes by silencing the gene expression at the protein and/or mRNA...
Hui Liu, Dong Yue, Yidong Chen, Shou-Jiang Gao, Yu...
BMCBI
2007
142views more  BMCBI 2007»
13 years 7 months ago
Improving model construction of profile HMMs for remote homology detection through structural alignment
Background: Remote homology detection is a challenging problem in Bioinformatics. Arguably, profile Hidden Markov Models (pHMMs) are one of the most successful approaches in addre...
Juliana S. Bernardes, Alberto M. R. Dávila,...
BMCBI
2007
144views more  BMCBI 2007»
13 years 7 months ago
Accelerated search for biomolecular network models to interpret high-throughput experimental data
Background: The functions of human cells are carried out by biomolecular networks, which include proteins, genes, and regulatory sites within DNA that encode and control protein e...
Suman Datta, Bahrad A. Sokhansanj
BMCBI
2006
139views more  BMCBI 2006»
13 years 7 months ago
Improvement in accuracy of multiple sequence alignment using novel group-to-group sequence alignment algorithm with piecewise li
Background: Multiple sequence alignment (MSA) is a useful tool in bioinformatics. Although many MSA algorithms have been developed, there is still room for improvement in accuracy...
Shinsuke Yamada, Osamu Gotoh, Hayato Yamana
BMCBI
2007
164views more  BMCBI 2007»
13 years 7 months ago
SEARCHPATTOOL: a new method for mining the most specific frequent patterns for binding sites with application to prokaryotic DNA
Background: Computational methods to predict transcription factor binding sites (TFBS) based on exhaustive algorithms are guaranteed to find the best patterns but are often limite...
Fathi Elloumi, Martha Nason