Accelerated search for biomolecular network models to interpret high-throughput experimental data

Background: The functions of human cells are carried out by biomolecular networks, which include proteins, genes, and regulatory sites within DNA that encode and control protein expression. Models of biomolecular network structure and dynamics can be inferred from highthroughput measurements of gene and protein expression. We build on our previously developed fuzzy logic method for bridging quantitative and qualitative biological data to address the challenges of noisy, low resolution high-throughput measurements, i.e., from gene expression microarrays. We employ an evolutionary search algorithm to accelerate the search for hypothetical fuzzy biomolecular network models consistent with a biological data set. We also develop a method to estimate the probability of a potential network model fitting a set of data by chance. The resulting metric provides an estimate of both model quality and dataset quality, identifying data that are too noisy to identify meaningful correlations between t...

• Type: Journal
• Year: 2007
• Where: BMCBI
• Authors: Suman Datta, Bahrad A. Sokhansanj
• Keywords: Biomolecular Network, BMCBI 2007, Evolutionary Search, Network Models