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ISDA
2006
IEEE
14 years 2 months ago
From Gene to Drug: A Proof of Concept for a Plausible Computational Pathway
The last decade has witnessed an exponential growth of sequence information in the field of biological macromolecules such as proteins and nucleic acids and their interactions wit...
Sandhya Shenoy, B. Jayaram, N. Latha, Pooja Narang...
BMCBI
2008
146views more  BMCBI 2008»
13 years 8 months ago
Can molecular dynamics simulations help in discriminating correct from erroneous protein 3D models?
Background: Recent approaches for predicting the three-dimensional (3D) structure of proteins such as de novo or fold recognition methods mostly rely on simplified energy potentia...
Jean-François Taly, Antoine Marin, Jean-Fra...
NAR
2011
214views Computer Vision» more  NAR 2011»
12 years 11 months ago
DAnCER: Disease-Annotated Chromatin Epigenetics Resource
Chromatin modification (CM) is a set of epigenetic processes that govern many aspects of DNA replication, transcription and repair. CM is carried out by groups of physically inter...
Andrei L. Turinsky, Brian Turner, Rosanne C. Borja...
BMCBI
2005
95views more  BMCBI 2005»
13 years 8 months ago
Commensurate distances and similar motifs in genetic congruence and protein interaction networks in yeast
Background: In a genetic interaction, the phenotype of a double mutant differs from the combined phenotypes of the underlying single mutants. When the single mutants have no growt...
Ping Ye, Brian D. Peyser, Forrest A. Spencer, Joel...
BMCBI
2010
128views more  BMCBI 2010»
13 years 8 months ago
Conserved residue clusters at protein-protein interfaces and their use in binding site identification
Background: Biological evolution conserves protein residues that are important for structure and function. Both protein stability and function often require a certain degree of st...
Mainak Guharoy, Pinak Chakrabarti