Most proteins function only when folded into a particular 3D configuration. Recently, a class of proteins has been discovered that do not fold into any particular configuration; t...
Background: An organism's ability to adapt to its particular environmental niche is of fundamental importance to its survival and proliferation. In the largest study of its k...
Michel Dumontier, Katerina Michalickova, Christoph...
Protein fold recognition is the prediction of protein’s tertiary structure (Fold) given the protein’s sequence without relying on sequence similarity. Using machine learning t...
Background: Solenoid repeat proteins of the Tetratrico Peptide Repeat (TPR) family are involved as scaffolds in a broad range of protein-protein interactions. Several resources ar...
Manjunatha R. Karpenahalli, Andrei N. Lupas, Johan...
Background: The ab initio protein folding problem consists of predicting protein tertiary structure from a given amino acid sequence by minimizing an energy function; it is one of...