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RECOMB
2002
Springer
14 years 9 months ago
Combining pairwise sequence similarity and support vector machines for remote protein homology detection
One key element in understanding the molecular machinery of the cell is to understand the meaning, or function, of each protein encoded in the genome. A very successful means of i...
Li Liao, William Stafford Noble
BMCBI
2007
135views more  BMCBI 2007»
13 years 8 months ago
Sequence similarity is more relevant than species specificity in probabilistic backtranslation
Background: Backtranslation is the process of decoding a sequence of amino acids into the corresponding codons. All synthetic gene design systems include a backtranslation module....
Alfredo Ferro, Rosalba Giugno, Giuseppe Pigola, Al...
BMCBI
2005
117views more  BMCBI 2005»
13 years 8 months ago
An SVM-based system for predicting protein subnuclear localizations
Background: The large gap between the number of protein sequences in databases and the number of functionally characterized proteins calls for the development of a fast computatio...
Zhengdeng Lei, Yang Dai
APBC
2004
125views Bioinformatics» more  APBC 2004»
13 years 10 months ago
A Dihedral Angle Database of Short Sub-sequences for Protein Structure Prediction
Protein structure prediction is considered to be the holy grail of bioinformatics. Ab initio and homology modelling are two important groups of methods used in protein structure p...
Saravanan Dayalan, Savitri Bevinakoppa, Heiko Schr...
BMCBI
2008
114views more  BMCBI 2008»
13 years 8 months ago
Combining classifiers for improved classification of proteins from sequence or structure
Background: Predicting a protein's structural or functional class from its amino acid sequence or structure is a fundamental problem in computational biology. Recently, there...
Iain Melvin, Jason Weston, Christina S. Leslie, Wi...