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» Principles and Models for Organizing the IT Function
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IPPS
2009
IEEE
14 years 2 months ago
Exploring FPGAs for accelerating the phylogenetic likelihood function
Driven by novel biological wet lab techniques such as pyrosequencing there has been an unprecedented molecular data explosion over the last 2-3 years. The growth of biological seq...
Nikolaos Alachiotis, Euripides Sotiriades, Apostol...
NAR
2011
257views Computer Vision» more  NAR 2011»
12 years 10 months ago
The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored
An essential prerequisite for any systems-level understanding of cellular functions is to correctly uncover and annotate all functional interactions among proteins in the cell. To...
Damian Szklarczyk, Andrea Franceschini, Michael Ku...
BMCBI
2007
157views more  BMCBI 2007»
13 years 7 months ago
Constructing gene co-expression networks and predicting functions of unknown genes by random matrix theory
Background: Large-scale sequencing of entire genomes has ushered in a new age in biology. One of the next grand challenges is to dissect the cellular networks consisting of many i...
Feng Luo, Yunfeng Yang, Jianxin Zhong, Haichun Gao...
AMAST
2004
Springer
14 years 1 months ago
A Science of Software Design
concerns, abstraction (particularly hierarchical abstraction), simplicity, and restricted visibility (locality of information). The overall goal behind these principles was stated ...
Don S. Batory
BMCBI
2007
118views more  BMCBI 2007»
13 years 7 months ago
A topological algorithm for identification of structural domains of proteins
Background: Identification of the structural domains of proteins is important for our understanding of the organizational principles and mechanisms of protein folding, and for ins...
Frank Emmert-Streib, Arcady R. Mushegian