Driven by novel biological wet lab techniques such as pyrosequencing there has been an unprecedented molecular data explosion over the last 2-3 years. The growth of biological seq...
An essential prerequisite for any systems-level understanding of cellular functions is to correctly uncover and annotate all functional interactions among proteins in the cell. To...
Damian Szklarczyk, Andrea Franceschini, Michael Ku...
Background: Large-scale sequencing of entire genomes has ushered in a new age in biology. One of the next grand challenges is to dissect the cellular networks consisting of many i...
concerns, abstraction (particularly hierarchical abstraction), simplicity, and restricted visibility (locality of information). The overall goal behind these principles was stated ...
Background: Identification of the structural domains of proteins is important for our understanding of the organizational principles and mechanisms of protein folding, and for ins...