Background: Most profile and motif databases strive to classify protein sequences into a broad spectrum of protein families. The next step of such database studies should include ...
Background: The relationship between divergence of amino-acid sequence and divergence of function among homologous proteins is complex. The assumption that homologs share function...
Vineet Sangar, Daniel J. Blankenberg, Naomi Altman...
Background: Phylogenetic analyses of protein families are used to define the evolutionary relationships between homologous proteins. The interpretation of protein-sequence phyloge...
Gareth Palidwor, Emmanuel G. Reynaud, Miguel A. An...
Many basic tasks in computational biology involve operations on individual DNA and protein sequences. These sequences, even when anonymized, are vulnerable to re-identification a...
Background: Proteins that are similar in sequence or structure may perform different functions in nature. In such cases, function cannot be inferred from sequence or structural si...