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BMCBI
2002
133views more  BMCBI 2002»
13 years 9 months ago
Identification and characterization of subfamily-specific signatures in a large protein superfamily by a hidden Markov model app
Background: Most profile and motif databases strive to classify protein sequences into a broad spectrum of protein families. The next step of such database studies should include ...
Kevin Truong, Mitsuhiko Ikura
BMCBI
2007
120views more  BMCBI 2007»
13 years 9 months ago
Quantitative sequence-function relationships in proteins based on gene ontology
Background: The relationship between divergence of amino-acid sequence and divergence of function among homologous proteins is complex. The assumption that homologs share function...
Vineet Sangar, Daniel J. Blankenberg, Naomi Altman...
BMCBI
2006
114views more  BMCBI 2006»
13 years 10 months ago
Taxonomic colouring of phylogenetic trees of protein sequences
Background: Phylogenetic analyses of protein families are used to define the evolutionary relationships between homologous proteins. The interpretation of protein-sequence phyloge...
Gareth Palidwor, Emmanuel G. Reynaud, Miguel A. An...
SP
2008
IEEE
100views Security Privacy» more  SP 2008»
14 years 4 months ago
Towards Practical Privacy for Genomic Computation
Many basic tasks in computational biology involve operations on individual DNA and protein sequences. These sequences, even when anonymized, are vulnerable to re-identification a...
Somesh Jha, Louis Kruger, Vitaly Shmatikov
BMCBI
2006
125views more  BMCBI 2006»
13 years 10 months ago
Automated functional classification of experimental and predicted protein structures
Background: Proteins that are similar in sequence or structure may perform different functions in nature. In such cases, function cannot be inferred from sequence or structural si...
Kai Wang, Ram Samudrala