Understanding how individual proteins are organized into complexes and pathways is a significant current challenge. We introduce new algorithms to infer protein complexes by combin...
Hailiang Huang, Lan V. Zhang, Frederick P. Roth, J...
The protein inference problem represents a major challenge in shotgun proteomics. Here we describe a novel Bayesian approach to address this challenge that incorporates the predict...
Yong Fuga Li, Randy J. Arnold, Yixue Li, Predrag R...
Alternative splicing (AS) is an important and frequent step in mammalian gene expression that allows a single gene to specify multiple products, and is crucial for the regulation ...
Ofer Shai, Brendan J. Frey, Quaid Morris, Qun Pan,...
Background: Identifying all protein complexes in an organism is a major goal of systems biology. In the past 18 months, the results of two genome-scale tandem affinity purificatio...
Protein interactions typically arise from a physical interaction of one or more small sites on the surface of the two proteins. Identifying these sites is very important for drug ...
Haidong Wang, Eran Segal, Asa Ben-Hur, Daphne Koll...