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BMCBI
2007
166views more  BMCBI 2007»
15 years 4 months ago
PathFinder: mining signal transduction pathway segments from protein-protein interaction networks
Background: A Signal transduction pathway is the chain of processes by which a cell converts an extracellular signal into a response. In most unicellular organisms, the number of ...
Gürkan Bebek, Jiong Yang
BMCBI
2010
88views more  BMCBI 2010»
15 years 4 months ago
Proteome scanning to predict PDZ domain interactions using support vector machines
Background: PDZ domains mediate protein-protein interactions involved in important biological processes through the recognition of short linear motifs in their target proteins. Tw...
Shirley Hui, Gary D. Bader
CTW
2007
121views more  CTW 2007»
15 years 4 months ago
Regularly irregular: how groups reconcile cross-cutting agendas and demand in healthcare
Abstract The flow of technical work in acute healthcare varies unpredictably, in patterns that occur regularly enough that they can be managed. Acute care organizations develop wa...
Christopher P. Nemeth, Mark Nunnally, Michael F. O...
ICDE
2007
IEEE
161views Database» more  ICDE 2007»
15 years 10 months ago
How to scalably and accurately skip past streams
Data stream methods look at each new item of the stream, perform a small number of operations while keeping a small amount of memory, and still perform muchneeded analyses. Howeve...
Supratik Bhattacharyya, André Madeira, S. M...
NIPS
2008
15 years 6 months ago
Optimization on a Budget: A Reinforcement Learning Approach
Many popular optimization algorithms, like the Levenberg-Marquardt algorithm (LMA), use heuristic-based "controllers" that modulate the behavior of the optimizer during ...
Paul Ruvolo, Ian R. Fasel, Javier R. Movellan