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BMCBI
2010
181views more  BMCBI 2010»
13 years 7 months ago
Intensity dependent estimation of noise in microarrays improves detection of differentially expressed genes
Background: In many microarray experiments, analysis is severely hindered by a major difficulty: the small number of samples for which expression data has been measured. When one ...
Amit Zeisel, Amnon Amir, Wolfgang J. Köstler,...
BMCBI
2007
97views more  BMCBI 2007»
13 years 7 months ago
SIRAC: Supervised Identification of Regions of Aberration in aCGH datasets
Background: Array comparative genome hybridization (aCGH) provides information about genomic aberrations. Alterations in the DNA copy number may cause the cell to malfunction, lea...
Carmen Lai, Hugo M. Horlings, Marc J. van de Vijve...
BMCBI
2008
130views more  BMCBI 2008»
13 years 7 months ago
An enhanced partial order curve comparison algorithm and its application to analyzing protein folding trajectories
Background: Understanding how proteins fold is essential to our quest in discovering how life works at the molecular level. Current computation power enables researchers to produc...
Hong Sun, Hakan Ferhatosmanoglu, Motonori Ota, Yus...
BMCBI
2007
182views more  BMCBI 2007»
13 years 7 months ago
Hybrid elementary flux analysis/nonparametric modeling: application for bioprocess control
Background: The progress in the "-omic" sciences has allowed a deeper knowledge on many biological systems with industrial interest. This knowledge is still rarely used ...
Ana P. Teixeira, Carlos Alves, Paula M. Alves, Man...
BMCBI
2008
323views more  BMCBI 2008»
13 years 7 months ago
A compatible exon-exon junction database for the identification of exon skipping events using tandem mass spectrum data
Background: Alternative splicing is an important gene regulation mechanism. It is estimated that about 74% of multi-exon human genes have alternative splicing. High throughput tan...
Fan Mo, Xu Hong, Feng Gao, Lin Du, Jun Wang, Gilbe...