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» Progressive multiple sequence alignments from triplets
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BMCBI
2007
99views more  BMCBI 2007»
13 years 7 months ago
Flexible mapping of homology onto structure with Homolmapper
Background: Over the past decade, a number of tools have emerged for the examination of homology relationships among protein sequences in a structural context. Most recent softwar...
Nathan C. Rockwell, J. Clark Lagarias
CSB
2003
IEEE
128views Bioinformatics» more  CSB 2003»
14 years 27 days ago
Degenerate Primer Design via Clustering
This paper describes a new strategy for designing degenerate primers for a given multiple alignment of amino acid sequences. Degenerate primers are useful for amplifying homologou...
Xintao Wei, David N. Kuhn, Giri Narasimhan
ECCB
2008
IEEE
14 years 2 months ago
Connect the dots: exposing hidden protein family connections from the entire sequence tree
Motivation: Mapping of remote evolutionary links is a classic computational problem of much interest. Relating protein families allows for functional and structural inference on u...
Yaniv Loewenstein, Michal Linial
BMCBI
2006
108views more  BMCBI 2006»
13 years 7 months ago
RibAlign: a software tool and database for eubacterial phylogeny based on concatenated ribosomal protein subunits
Background: Until today, analysis of 16S ribosomal RNA (rRNA) sequences has been the de-facto gold standard for the assessment of phylogenetic relationships among prokaryotes. How...
Hanno Teeling, Frank Oliver Glöckner
GCB
2000
Springer
137views Biometrics» more  GCB 2000»
13 years 11 months ago
Detecting Sporadic Recombination in DNA Alignments with Hidden Markov Models
Conventional phylogenetic tree estimation methods assume that all sites in a DNA multiple alignment have the same evolutionary history. This assumption is violated in data sets fro...
Dirk Husmeier, Frank Wright