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BMCBI
2007
142views more  BMCBI 2007»
13 years 7 months ago
Improving model construction of profile HMMs for remote homology detection through structural alignment
Background: Remote homology detection is a challenging problem in Bioinformatics. Arguably, profile Hidden Markov Models (pHMMs) are one of the most successful approaches in addre...
Juliana S. Bernardes, Alberto M. R. Dávila,...
BMCBI
2007
120views more  BMCBI 2007»
13 years 7 months ago
Quantitative sequence-function relationships in proteins based on gene ontology
Background: The relationship between divergence of amino-acid sequence and divergence of function among homologous proteins is complex. The assumption that homologs share function...
Vineet Sangar, Daniel J. Blankenberg, Naomi Altman...
NAR
2000
182views more  NAR 2000»
13 years 7 months ago
tmRDB (tmRNA database)
Maintained at the University of Texas Health Science Center at Tyler, Texas, the tmRNA database (tmRDB) is accessible at the URL http://psyche.uthct.edu/dbs/ tmRDB/tmRDB.html with...
Christian Zwieb, Jacek Wower
WABI
2010
Springer
167views Bioinformatics» more  WABI 2010»
13 years 5 months ago
Quantifying the Strength of Natural Selection of a Motif Sequence
Quantification of selective pressures on regulatory sequences is a central question in studying the evolution of gene regulatory networks. Previous methods focus primarily on sing...
Chen-Hsiang Yeang
NAR
2011
274views Computer Vision» more  NAR 2011»
13 years 2 months ago
A series of PDB related databases for everyday needs
The Protein Data Bank (PDB) is the world-wide repository of macromolecular structure information. We present a series of databases that run parallel to the PDB. Each database hold...
Robbie P. Joosten, Tim A. H. te Beek, Elmar Kriege...