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» Protein folding and the robustness of cells
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BMCBI
2010
150views more  BMCBI 2010»
13 years 7 months ago
MCL-CAw: a refinement of MCL for detecting yeast complexes from weighted PPI networks by incorporating core-attachment structure
Background: The reconstruction of protein complexes from the physical interactome of organisms serves as a building block towards understanding the higher level organization of th...
Sriganesh Srihari, Kang Ning, Hon Wai Leong
BMCBI
2007
109views more  BMCBI 2007»
13 years 7 months ago
A domain-based approach to predict protein-protein interactions
Background: Knowing which proteins exist in a certain organism or cell type and how these proteins interact with each other are necessary for the understanding of biological proce...
Mudita Singhal, Haluk Resat
BMCBI
2010
140views more  BMCBI 2010»
13 years 5 months ago
An improved machine learning protocol for the identification of correct Sequest search results
Background: Mass spectrometry has become a standard method by which the proteomic profile of cell or tissue samples is characterized. To fully take advantage of tandem mass spectr...
Morten Kallberg, Hui Lu
BMCBI
2006
124views more  BMCBI 2006»
13 years 7 months ago
Network-based de-noising improves prediction from microarray data
Background: Prediction of human cell response to anti-cancer drugs (compounds) from microarray data is a challenging problem, due to the noise properties of microarrays as well as...
Tsuyoshi Kato, Yukio Murata, Koh Miura, Kiyoshi As...
BMCBI
2010
154views more  BMCBI 2010»
13 years 5 months ago
Knowledge-based matrix factorization temporally resolves the cellular responses to IL-6 stimulation
Background: External stimulations of cells by hormones, cytokines or growth factors activate signal transduction pathways that subsequently induce a re-arrangement of cellular gen...
Andreas Kowarsch, Florian Blöchl, Sebastian B...