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» Protein homology detection using string alignment kernels
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IJDMB
2008
128views more  IJDMB 2008»
13 years 7 months ago
Protein homology detection with biologically inspired features and interpretable statistical models
: Computational classification of proteins using methods such as string kernels and Fisher-SVM has demonstrated great success. However, the resulting models do not offer an immedia...
Pai-Hsi Huang, Vladimir Pavlovic
NIPS
2008
13 years 9 months ago
Scalable Algorithms for String Kernels with Inexact Matching
We present a new family of linear time algorithms based on sufficient statistics for string comparison with mismatches under the string kernels framework. Our algorithms improve t...
Pavel P. Kuksa, Pai-Hsi Huang, Vladimir Pavlovic
JCB
2000
107views more  JCB 2000»
13 years 7 months ago
A Discriminative Framework for Detecting Remote Protein Homologies
A new method for detecting remote protein homologies is introduced and shown to perform well in classifying protein domains by SCOP superfamily. The method is a variant of support...
Tommi Jaakkola, Mark Diekhans, David Haussler
BMCBI
2010
101views more  BMCBI 2010»
13 years 7 months ago
Enrichment of homologs in insignificant BLAST hits by co-complex network alignment
Background: Homology is a crucial concept in comparative genomics. The algorithm probably most widely used for homology detection in comparative genomics, is BLAST. Usually a stri...
Like Fokkens, Sandra M. C. Botelho, Jos Boekhorst,...
BMCBI
2007
144views more  BMCBI 2007»
13 years 7 months ago
Motif kernel generated by genetic programming improves remote homology and fold detection
Background: Protein remote homology detection is a central problem in computational biology. Most recent methods train support vector machines to discriminate between related and ...
Tony Håndstad, Arne J. H. Hestnes, Pål...