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BIOINFORMATICS
2008
119views more  BIOINFORMATICS 2008»
13 years 7 months ago
Optimal design of thermally stable proteins
Motivation: For many biotechnological purposes, it is desirable to redesign proteins to be more structurally and functionally stable at higher temperatures. For example, chemical ...
Ryan M. Bannen, Vanitha Suresh, George N. Phillips...
JCB
2007
136views more  JCB 2007»
13 years 7 months ago
A Structure-Based Flexible Search Method for Motifs in RNA
The discovery of non-coding RNA (ncRNA) motifs and their role in regulating gene expression has recently attracted considerable attention. The goal is to discover these motifs in ...
Isana Veksler-Lublinsky, Michal Ziv-Ukelson, Danny...
ISBI
2007
IEEE
14 years 1 months ago
Segmentation of Mammosphere Structures from Volumetric Data
3D cell culture assays have emerged as the basis of an improved model system for evaluating therapeutic agents, molecular probes, and exogenous stimuli. However, there is a gap in...
Ju Han, Hang Chang, Qing Yang, Mary Helen Barcello...
NAR
2011
207views Computer Vision» more  NAR 2011»
12 years 10 months ago
PSORTdb - an expanded, auto-updated, user-friendly protein subcellular localization database for Bacteria and Archaea
The subcellular localization (SCL) of a microbial protein provides clues about its function, its suitability as a drug, vaccine or diagnostic target and aids experimental design. ...
Nancy Y. Yu, Matthew R. Laird, Cory Spencer, Fiona...
RECOMB
2005
Springer
14 years 8 months ago
Pairwise Local Alignment of Protein Interaction Networks Guided by Models of Evolution
Abstract. With ever increasing amount of available data on protein-protein interaction (PPI) networks and research revealing that these networks evolve at a modular level, discover...
Mehmet Koyutürk, Ananth Grama, Wojciech Szpan...