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BMCBI
2010
155views more  BMCBI 2010»
15 years 6 months ago
BISMA - Fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences
Background: Bisulfite sequencing is a popular method to analyze DNA methylation patterns at high resolution. A region of interest is targeted by PCR and about 20-50 subcloned DNA ...
Christian Rohde, Yingying Zhang, Richard Reinhardt...
BMCBI
2008
96views more  BMCBI 2008»
15 years 6 months ago
Use of normalization methods for analysis of microarrays containing a high degree of gene effects
Background: High-throughput microarrays are widely used to study gene expression across tissues and developmental stages. Analysis of gene expression data is challenging in these ...
Terri T. Ni, William J. Lemon, Yu Shyr, Tao P. Zho...
BMCBI
2007
129views more  BMCBI 2007»
15 years 6 months ago
A novel approach to sequence validating protein expression clones with automated decision making
Background: Whereas the molecular assembly of protein expression clones is readily automated and routinely accomplished in high throughput, sequence verification of these clones i...
Elena Taycher, Andreas Rolfs, Yanhui Hu, Dongmei Z...
BMCBI
2008
133views more  BMCBI 2008»
15 years 6 months ago
A Web-based and Grid-enabled dChip version for the analysis of large sets of gene expression data
Background: Microarray techniques are one of the main methods used to investigate thousands of gene expression profiles for enlightening complex biological processes responsible f...
Luca Corradi, Marco Fato, Ivan Porro, Silvia Scagl...
BMCBI
2008
141views more  BMCBI 2008»
15 years 6 months ago
Ontology-guided data preparation for discovering genotype-phenotype relationships
Complexity of post-genomic data and multiplicity of mining strategies are two limits to Knowledge Discovery in Databases (KDD) in life sciences. Because they provide a semantic fr...
Adrien Coulet, Malika Smaïl-Tabbone, Pascale ...