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» Reconstructing the pre-doubling genome
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ICCS
2005
Springer
14 years 3 months ago
SWAT: A New Spliced Alignment Tool Tailored for Handling More Sequencing Errors
Abstract. There are several computer programs that align mRNA with its genomic counterpart to determine exon boundaries. Though most of these programs perform such alignment effici...
Yifeng Li, Hesham H. Ali
BMCBI
2008
108views more  BMCBI 2008»
13 years 10 months ago
Empirical methods for controlling false positives and estimating confidence in ChIP-Seq peaks
Background: High throughput signature sequencing holds many promises, one of which is the ready identification of in vivo transcription factor binding sites, histone modifications...
David A. Nix, Samir J. Courdy, Kenneth M. Boucher
NAR
2007
81views more  NAR 2007»
13 years 9 months ago
Pseudogene.org: a comprehensive database and comparison platform for pseudogene annotation
The Pseudogene.org database serves as a comprehensive repository for pseudogene sequence annotation. The definition of a pseudogene varies within the literature, resulting in sign...
John E. Karro, Yangpan Yan, Deyou Zheng, Zhaolei Z...
RECOMB
2009
Springer
14 years 4 months ago
Inferring the Recent Duplication History of a Gene Cluster
Abstract. Much important evolutionary activity occurs in gene clusters, where a copy of a gene may be free to evolve new functions. Computational methods to extract evolutionary in...
Giltae Song, Louxin Zhang, Tomás Vinar, Web...
WABI
2001
Springer
112views Bioinformatics» more  WABI 2001»
14 years 2 months ago
Finding an Optimal Inversion Median: Experimental Results
We derive a branch-and-bound algorithm to find an optimal inversion median of three signed permutations. The algorithm prunes to manageable size an extremely large search tree usi...
Adam C. Siepel, Bernard M. E. Moret