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BMCBI
2006
92views more  BMCBI 2006»
13 years 7 months ago
A jumping profile Hidden Markov Model and applications to recombination sites in HIV and HCV genomes
Background: Jumping alignments have recently been proposed as a strategy to search a given multiple sequence alignment A against a database. Instead of comparing a database sequen...
Anne-Kathrin Schultz, Ming Zhang, Thomas Leitner, ...
BMCBI
2006
88views more  BMCBI 2006»
13 years 7 months ago
RiboSubstrates: a web application addressing the cleavage specificities of ribozymes in designated genomes
Background: RNA-dependent gene silencing is becoming a routine tool used in laboratories worldwide. One of the important remaining hurdles in the selection of the target sequence,...
Jean-François Lucier, Lucien Junior Bergero...
BMCBI
2006
125views more  BMCBI 2006»
13 years 7 months ago
Development of an open source laboratory information management system for 2-D gel electrophoresis-based proteomics workflow
Background: In the post-genome era, most research scientists working in the field of proteomics are confronted with difficulties in management of large volumes of data, which they...
Hiraku Morisawa, Mikako Hirota, Tosifusa Toda
BMCBI
2006
117views more  BMCBI 2006»
13 years 7 months ago
Incorporating background frequency improves entropy-based residue conservation measures
Background: Several entropy-based methods have been developed for scoring sequence conservation in protein multiple sequence alignments. High scoring amino acid positions may corr...
Kai Wang, Ram Samudrala
BSL
2006
114views more  BSL 2006»
13 years 7 months ago
Schemata: The Concept of Schema in the History of Logic
Schemata have played important roles in logic since Aristotle's Prior Analytics. The syllogistic figures and moods can be taken to be argument schemata as can the rules of the...
John Corcoran