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GLVLSI
2003
IEEE
175views VLSI» more  GLVLSI 2003»
14 years 28 days ago
A custom FPGA for the simulation of gene regulatory networks
We present a unique FPGA that uses a mix of digital and large-signal analog computation for the simulation of gene regulatory networks. The prototype IC consists of a 4x5 array of...
Ilias Tagkopoulos, Charles A. Zukowski, German Cav...
WABI
2009
Springer
142views Bioinformatics» more  WABI 2009»
14 years 2 months ago
Back-Translation for Discovering Distant Protein Homologies
Background: Frameshift mutations in protein-coding DNA sequences produce a drastic change in the resulting protein sequence, which prevents classic protein alignment methods from ...
Marta Gîrdea, Laurent Noé, Gregory Ku...
BMCBI
2005
118views more  BMCBI 2005»
13 years 7 months ago
Variation in structural location and amino acid conservation of functional sites in protein domain families
Background: The functional sites of a protein present important information for determining its cellular function and are fundamental in drug design. Accordingly, accurate methods...
Birgit Pils, Richard R. Copley, Jörg Schultz
BMCBI
2006
117views more  BMCBI 2006»
13 years 7 months ago
Gene Designer: a synthetic biology tool for constructing artificial DNA segments
Background: Direct synthesis of genes is rapidly becoming the most efficient way to make functional genetic constructs and enables applications such as codon optimization, RNAi re...
Alan Villalobos, Jon E. Ness, Claes Gustafsson, Je...
BMCBI
2010
101views more  BMCBI 2010»
13 years 7 months ago
Optimizing structural modeling for a specific protein scaffold: knottins or inhibitor cystine knots
Background: Knottins are small, diverse and stable proteins with important drug design potential. They can be classified in 30 families which cover a wide range of sequences (1621...
Jérôme Gracy, Laurent Chiche