Background: The translational efficiency of an mRNA can be modulated by upstream open reading frames (uORFs) present in certain genes. A uORF can attenuate translation of the main...
Marija Cvijovic, Daniel Dalevi, Elizabeth Bilsland...
Background: MicroRNAs (miRNAs) are endogenous 21 to 23-nucleotide RNA molecules that regulate protein-coding gene expression in plants and animals via the RNA interference pathway...
Background: Gene silencing using exogenous small interfering RNAs (siRNAs) is now a widespread molecular tool for gene functional study and new-drug target identification. The key...
Qi Liu, Qian Xu, Vincent Wenchen Zheng, Hong Xue, ...
Protein-protein interactions (PPI) play a key role in many biological systems. Over the past few years, an explosion in availability of functional biological data obtained from hi...
Distinct, local structures are frequently correlated with functional RNA elements involved in posttranscriptional regulation of gene expression. Discovery of microRNAs (miRNAs) su...