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BMCBI
2007
104views more  BMCBI 2007»
13 years 8 months ago
Identification of putative regulatory upstream ORFs in the yeast genome using heuristics and evolutionary conservation
Background: The translational efficiency of an mRNA can be modulated by upstream open reading frames (uORFs) present in certain genes. A uORF can attenuate translation of the main...
Marija Cvijovic, Daniel Dalevi, Elizabeth Bilsland...
BMCBI
2005
136views more  BMCBI 2005»
13 years 8 months ago
Identification of clustered microRNAs using an ab initio prediction method
Background: MicroRNAs (miRNAs) are endogenous 21 to 23-nucleotide RNA molecules that regulate protein-coding gene expression in plants and animals via the RNA interference pathway...
Alain Sewer, Nicodème Paul, Pablo Landgraf,...
BMCBI
2010
119views more  BMCBI 2010»
13 years 8 months ago
Multi-task learning for cross-platform siRNA efficacy prediction: an in-silico study
Background: Gene silencing using exogenous small interfering RNAs (siRNAs) is now a widespread molecular tool for gene functional study and new-drug target identification. The key...
Qi Liu, Qian Xu, Vincent Wenchen Zheng, Hong Xue, ...
JIB
2006
220views more  JIB 2006»
13 years 8 months ago
An assessment of machine and statistical learning approaches to inferring networks of protein-protein interactions
Protein-protein interactions (PPI) play a key role in many biological systems. Over the past few years, an explosion in availability of functional biological data obtained from hi...
Fiona Browne, Haiying Wang, Huiru Zheng, Francisco...
CSB
2003
IEEE
110views Bioinformatics» more  CSB 2003»
14 years 2 months ago
Statistical Inference for Well-ordered Structures in Nucleotide Sequences
Distinct, local structures are frequently correlated with functional RNA elements involved in posttranscriptional regulation of gene expression. Discovery of microRNAs (miRNAs) su...
Shu-Yun Le, Jih-H. Chen, Jacob V. Maizel