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» Simulating the Hallmarks of Cancer
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CEC
2010
IEEE
13 years 11 months ago
Accelerated optimisation of chemotherapy dose schedules using fitness inheritance
Abstract-- Cancer treatment by chemotherapy involves multiple applications of toxic drugs over a period of time. Optimising the schedule of these treatments can improve the outcome...
Robert Barbour, David W. Corne, John A. W. McCall
BIOSYSTEMS
2008
72views more  BIOSYSTEMS 2008»
13 years 10 months ago
The manipulation of calcium oscillations by harnessing self-organisation
This paper investigates how self-organisation might be harnessed for the manipulation and control of calcium oscillations. Calcium signalling mechanisms are responsible for a numb...
Cristina Costa Santini, Andy M. Tyrrell
EJASP
2010
132views more  EJASP 2010»
13 years 4 months ago
Uncovering Transcriptional Regulatory Networks by Sparse Bayesian Factor Model
The problem of uncovering transcriptional regulation by transcription factors (TFs) based on microarray data is considered. A novel Bayesian sparse correlated rectified factor mod...
Jia Meng, Jianqiu Zhang, Yuan (Alan) Qi, Yidong Ch...
APVIS
2009
13 years 11 months ago
Visualization of signal transduction processes in the crowded environment of the cell
In this paper, we propose a stochastic simulation to model and analyze cellular signal transduction. The high number of objects in a simulation requires advanced visualization tec...
Martin Falk, Michael Klann, Matthias Reuss, Thomas...
BMCBI
2007
104views more  BMCBI 2007»
13 years 10 months ago
Comparative evaluation of gene-set analysis methods
Background: Multiple data-analytic methods have been proposed for evaluating gene-expression levels in specific biological pathways, assessing differential expression associated w...
Qi Liu, Irina Dinu, Adeniyi J. Adewale, John D. Po...