We present a novel classification-based algorithm called GeneClass for learning to predict gene regulatory response. Our approach is motivated by the hypothesis that in simple orga...
Manuel Middendorf, Anshul Kundaje, Chris Wiggins, ...
Armed with increasingly fast supercomputers and greater knowledge of the molecular mechanisms of gene expression, it is now practical to numerically simulate complex networks of r...
Abstract. Understanding the regulatory mechanisms that are responsible for an organism's response to environmental changes is an important question in molecular biology. A fir...
Oliver Stegle, Katherine J. Denby, David L. Wild, ...
Background: Novel strategies are required in order to handle the huge amount of data produced by microarray technologies. To infer gene regulatory networks, the first step is to f...
Background: Many research results show that the biological systems are composed of functional modules. Members in the same module usually have common functions. This is useful inf...