31 search results - page 1 / 7 » Somatic evolution of cancer |
RECOMB
2004
Springer
14 years 11 months ago
2004
Springer
We study a situation that arises in the somatic evolution of cancer. Consider a finite population of replicating cells and a sequence of mutations: type 0 can mutate to type 1, wh...
NAR
2011
13 years 2 months ago
2011
COSMIC (http://www.sanger.ac.uk/cosmic) curates comprehensive information on somatic mutations in human cancer. Release v48 (July 2010) describes over 136 000 coding mutations in ...
BMCBI
2010
13 years 11 months ago
2010
Background: Human cancer is caused by the accumulation of tumor-specific mutations in oncogenes and tumor suppressors that confer a selective growth advantage to cells. As a conse...
ICASSP
2011
IEEE
13 years 2 months ago
2011
IEEE
In this paper we model and simulate a biological system describing the evolution of cancer stem cells into tumors. Starting from some basic hypotheses about the behavior of these ...
BMCBI
2008
13 years 11 months ago
2008
Background: DNA sequencing is now emerging as an important component in biomedical studies of diseases like cancer. Short-read, highly parallel sequencing instruments are expected...