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BMCBI
2002
128views more  BMCBI 2002»
13 years 7 months ago
Correlating overrepresented upstream motifs to gene expression: a computational approach to regulatory element discovery in euka
Background: Gene regulation in eukaryotes is mainly effected through transcription factors binding to rather short recognition motifs generally located upstream of the coding regi...
Michele Caselle, Ferdinando Di Cunto, Paolo Prover...
BMCBI
2008
126views more  BMCBI 2008»
13 years 7 months ago
Relating gene expression data on two-component systems to functional annotations in Escherichia coli
Background: Obtaining physiological insights from microarray experiments requires computational techniques that relate gene expression data to functional information. Traditionall...
Anne M. Denton, Jianfei Wu, Megan K. Townsend, Pre...
BMCBI
2006
123views more  BMCBI 2006»
13 years 7 months ago
Permutation test for periodicity in short time series data
Background: Periodic processes, such as the circadian rhythm, are important factors modulating and coordinating transcription of genes governing key metabolic pathways. Theoretica...
Andrey A. Ptitsyn, Sanjin Zvonic, Jeffrey M. Gimbl...
BMCBI
2010
193views more  BMCBI 2010»
13 years 7 months ago
Probe set filtering increases correlation between Affymetrix GeneChip and qRT-PCR expression measurements
Background: Affymetrix GeneChip microarrays are popular platforms for expression profiling in two types of studies: detection of differential expression computed by p-values of t-...
Jakub Mieczkowski, Magdalena E. Tyburczy, Michal D...
BMCBI
2006
86views more  BMCBI 2006»
13 years 7 months ago
The impact of sample imbalance on identifying differentially expressed genes
Background: Recently several statistical methods have been proposed to identify genes with differential expression between two conditions. However, very few studies consider the p...
Kun Yang, Jianzhong Li, Hong Gao