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» Statistical significance in biological sequence analysis
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BMCBI
2011
12 years 11 months ago
Proteinortho: Detection of (Co-)Orthologs in Large-Scale Analysis
Background: Orthology analysis is an important part of data analysis in many areas of bioinformatics such as comparative genomics and molecular phylogenetics. The ever-increasing ...
Marcus Lechner, Sven Findeiß, Lydia Steiner,...
RECOMB
2006
Springer
14 years 8 months ago
New Methods for Detecting Lineage-Specific Selection
Abstract. So far, most methods for identifying sequences under selection based on comparative sequence data have either assumed selectional pressures are the same across all branch...
Adam C. Siepel, Katherine S. Pollard, David Haussl...
RECOMB
2004
Springer
14 years 8 months ago
Designing multiple simultaneous seeds for DNA similarity search
The challenge of similarity search in massive DNA sequence databases has inspired major changes in BLAST-style alignment tools, which accelerate search by inspecting only pairs of...
Yanni Sun, Jeremy Buhler
BMCBI
2005
153views more  BMCBI 2005»
13 years 7 months ago
Mining published lists of cancer related microarray experiments: Identification of a gene expression signature having a critical
Background: Routine application of gene expression microarray technology is rapidly producing large amounts of data that necessitate new approaches of analysis. The analysis of a ...
Giacomo Finocchiaro, Francesco Mancuso, Heiko M&uu...
BMCBI
2006
130views more  BMCBI 2006»
13 years 7 months ago
CARMA: A platform for analyzing microarray datasets that incorporate replicate measures
Background: The incorporation of statistical models that account for experimental variability provides a necessary framework for the interpretation of microarray data. A robust ex...
Kevin A. Greer, Matthew R. McReynolds, Heddwen L. ...