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BMCBI
2010
144views more  BMCBI 2010»
13 years 5 months ago
Optimizing Transformations for Automated, High Throughput Analysis of Flow Cytometry Data
Background: In a high throughput setting, effective flow cytometry data analysis depends heavily on proper data preprocessing. While usual preprocessing steps of quality assessmen...
Greg Finak, Juan-Manuel Perez, Andrew Weng, Raphae...
BIOINFORMATICS
2011
13 years 5 months ago
Inverse perturbation for optimal intervention in gene regulatory networks
Motivation: Analysis and intervention in the dynamics of gene regulatory networks is at the heart of emerging efforts in the development of modern treatment of numerous ailments i...
Nidhal Bouaynaya, Roman Shterenberg, Dan Schonfeld
BMCBI
2011
13 years 5 months ago
PICS-Ord: Unlimited Coding of Ambiguous Regions by Pairwise Identity and Cost Scores Ordination
Background: We present a novel method to encode ambiguously aligned regions in fixed multiple sequence alignments by ‘Pairwise Identity and Cost Scores Ordination’ (PICS-Ord)....
Robert K. Luecking, Brendan P. Hodkinson, Alexandr...
BMCBI
2011
13 years 5 months ago
Accurate statistics for local sequence alignment with position-dependent scoring by rare-event sampling
Background: Molecular database search tools need statistical models to assess the significance for the resulting hits. In the classical approach one asks the question how probable...
Stefan Wolfsheimer, Inke Herms, Sven Rahmann, Alex...
BMCBI
2011
13 years 5 months ago
A quality metric for homology modeling: the H-factor
Background: The analysis of protein structures provides fundamental insight into most biochemical functions and consequently into the cause and possible treatment of diseases. As ...
Eric di Luccio, Patrice Koehl
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