Background: Protein kinases play crucial roles in cell growth, differentiation, and apoptosis. Abnormal function of protein kinases can lead to many serious diseases, such as canc...
Study of protein interaction networks is crucial to post-genomic systems biology. Aided by highthroughput screening technologies, biologists are rapidly accumulating protein-prote...
Jake Yue Chen, Andrey Y. Sivachenko, Russell Bell,...
The Biological General Repository for Interaction Datasets (BioGRID) database (http://www. thebiogrid.org) was developed to house and distribute collections of protein and genetic...
Bobby-Joe Breitkreutz, Chris Stark, Teresa Reguly,...
Background: Docking algorithms are developed to predict in which orientation two proteins are likely to bind under natural conditions. The currently used methods usually consist o...
Abstract. Protein conformational changes play a critical role in biological functions such as ligand-protein and protein-protein interactions. Due to the noise in structural data, ...