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BMCBI
2011
12 years 11 months ago
2011
Background: Chromatin immunoprecipitation (ChIP), coupled with massively parallel short-read sequencing (seq) is used to probe chromatin dynamics. Although there are many algorith...
BMCBI
2011
12 years 11 months ago
2011
Background: Using microarray and sequencing platforms, a large number of copy number variations (CNVs) have been identified in humans. In practice, because our human genome is a d...
BMCBI
2011
12 years 11 months ago
2011
Background: Elucidating the exact relationship between gene copy number and expression would enable identification of regulatory mechanisms of abnormal gene expression and biologi...
BMCBI
2011
12 years 11 months ago
2011
Background: Estimation of allele frequency is of fundamental importance in population genetic analyses and in association mapping. In most studies using next-generation sequencing...
BMCBI
2011
12 years 11 months ago
2011
Background: Statistical methods for ranking differentially expressed genes (DEGs) from gene expression data should be evaluated with regard to high sensitivity, specificity, and r...